Some human proteins may simultaneously exist at, or move between, two or more subcellular locations. Proteins with multiple locations or dynamic features of this kind are particularly interesting because they may have some special biological functions intriguing to investigators in both basic research and drug discovery.To deal with these proteins, we have modified the ensemble classifier Hum-PLoc to cover cases of multiple locations as well. The modified classifier is called Hum-mPLoc.

Caveat

Application scope: The predictor is for human protein samples that covers the following 14 subcellular locations: (1) centriole, (2) cytoplasm, (3) cytoskeleton, (4) endoplasmic reticulum, (5) endosome , (6) extracell, (7) Golgi apparatus, (8) lysosome, (9) microsome, (10) mitochondrion, (11) nucleus, (12) peroxisome, (13) plasma membrane, and (14) synapse (See the Figure below). Stop prediction if the query protein is known not a human protein or not one of the above 14 locations, because the result obtained will not make any sense.