Some human proteins may simultaneously exist at, or move between, two or more subcellular locations.
Proteins with multiple locations or dynamic features of this kind are particularly interesting
because they may have some special biological functions intriguing to investigators in both basic research
and drug discovery.To deal with these proteins, we have modified the ensemble classifier
Hum-PLoc to cover cases of multiple locations
as well. The modified classifier is called Hum-mPLoc. |
Hum-mPLoc was firstly published in Biochemical and Biophysical Research Communications (2007, 355, 1006-1011) and now it has been updated to its 2.0 version. Please refer the text for details.
Application scope: The predictor is for human protein
samples that covers the following 14 subcellular locations:
(1) centriole, (2) cytoplasm, (3) cytoskeleton, (4) endoplasmic reticulum, (5) endosome , (6) extracell, (7) Golgi apparatus, (8) lysosome, (9) microsome, (10) mitochondrion, (11) nucleus, (12) peroxisome, (13) plasma membrane, and (14) synapse (See the Figure below).
Stop prediction if the query protein is known not a human protein or not one of the above 14 locations, because the result obtained will not make any sense.