Signal-3L 2.0: Improved signal peptide predictions
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Please select the species:
Eukaryotic Gram-positive Gram-negative
Please input one or more (up to 10) protein sequences in fasta format:  (Example
Please input the email address where the prediction results will be sent to:
This is the improved Signal-3L 2.0 version. The former 1.0 server is available at:
  • Yi-Ze Zhang and Hong-Bin Shen, "Signal-3L 2.0: A hierarchical mixture model for enhancing protein signal peptide prediction by incorporating residue-domain cross level features", Journal of Chemical Information and Modeling, 2017, 57: 988-999.
  • Hong-Bin Shen and Kuo-Chen Chou, "Signal-3L: a 3-layer approach for predicting signal peptides", Biochemical and Biophysical Research Communications, 2007, 363: 297-303.
  • Contact @ Hong-Bin